VGTU was the first university in Lithuania who started working with High Performance Computing. IBM SP was installed in 1998. The Laboratory of Parallel Computing was founded in 2000. The Beowulf cluster was built in 2002. The Lithuanian record of the best parallel performance on cluster “Vilkas” was achieved in 2005. The Laboratory of Parallel Computing started activity in grid computing at 2004 when first testbed grid based on ARC middleware was installed together with colleagues from Vilnius University and Kaunas University of Technology. Shortly after that gLite cluster was built and connected to Litgrid and BalticGrid infrastructure. In the laboratory, research activity is focused on parallel and distributed computing, grid technologies, computational methods, visualization and software engineering. Actual applications of material sciences, nano-particles, engineering, computational fluid dynamics, multi-physics and bioengineering has been solving on the computer clusters supported by personnel of the Laboratory of Parallel Computing.